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Multistep resistance selection of ridinilazole, CRS3123, and <t>rifampicin</t> against <t>Enterococcus</t> species. (A) E. faecalis ATCC 29,212 and (B) E. faecium NR-31,909 were serially passaged over a 10-day period in the presence of ridinilazole, CRS3123, or rifampicin. The MICs of each compound were determined daily using the broth microdilution method.
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Multistep resistance selection of ridinilazole, CRS3123, and <t>rifampicin</t> against <t>Enterococcus</t> species. (A) E. faecalis ATCC 29,212 and (B) E. faecium NR-31,909 were serially passaged over a 10-day period in the presence of ridinilazole, CRS3123, or rifampicin. The MICs of each compound were determined daily using the broth microdilution method.
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Multistep resistance selection of ridinilazole, CRS3123, and <t>rifampicin</t> against <t>Enterococcus</t> species. (A) E. faecalis ATCC 29,212 and (B) E. faecium NR-31,909 were serially passaged over a 10-day period in the presence of ridinilazole, CRS3123, or rifampicin. The MICs of each compound were determined daily using the broth microdilution method.
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Multistep resistance selection of ridinilazole, CRS3123, and <t>rifampicin</t> against <t>Enterococcus</t> species. (A) E. faecalis ATCC 29,212 and (B) E. faecium NR-31,909 were serially passaged over a 10-day period in the presence of ridinilazole, CRS3123, or rifampicin. The MICs of each compound were determined daily using the broth microdilution method.
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Multistep resistance selection of ridinilazole, CRS3123, and <t>rifampicin</t> against <t>Enterococcus</t> species. (A) E. faecalis ATCC 29,212 and (B) E. faecium NR-31,909 were serially passaged over a 10-day period in the presence of ridinilazole, CRS3123, or rifampicin. The MICs of each compound were determined daily using the broth microdilution method.
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Multistep resistance selection of ridinilazole, CRS3123, and <t>rifampicin</t> against <t>Enterococcus</t> species. (A) E. faecalis ATCC 29,212 and (B) E. faecium NR-31,909 were serially passaged over a 10-day period in the presence of ridinilazole, CRS3123, or rifampicin. The MICs of each compound were determined daily using the broth microdilution method.
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Multistep resistance selection of ridinilazole, CRS3123, and <t>rifampicin</t> against <t>Enterococcus</t> species. (A) E. faecalis ATCC 29,212 and (B) E. faecium NR-31,909 were serially passaged over a 10-day period in the presence of ridinilazole, CRS3123, or rifampicin. The MICs of each compound were determined daily using the broth microdilution method.
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Multistep resistance selection of ridinilazole, CRS3123, and rifampicin against Enterococcus species. (A) E. faecalis ATCC 29,212 and (B) E. faecium NR-31,909 were serially passaged over a 10-day period in the presence of ridinilazole, CRS3123, or rifampicin. The MICs of each compound were determined daily using the broth microdilution method.

Journal: Scientific Reports

Article Title: Repurposing antibacterial drugs identifies ridinilazole and CRS3123 as promising candidates against vancomycin-resistant enterococci

doi: 10.1038/s41598-025-29583-1

Figure Lengend Snippet: Multistep resistance selection of ridinilazole, CRS3123, and rifampicin against Enterococcus species. (A) E. faecalis ATCC 29,212 and (B) E. faecium NR-31,909 were serially passaged over a 10-day period in the presence of ridinilazole, CRS3123, or rifampicin. The MICs of each compound were determined daily using the broth microdilution method.

Article Snippet: Fig. 6 Multistep resistance selection of ridinilazole, CRS3123, and rifampicin against Enterococcus species. (A) E. faecalis ATCC 29,212 and (B) E. faecium NR-31,909 were serially passaged over a 10-day period in the presence of ridinilazole, CRS3123, or rifampicin.

Techniques: Selection